Learning biological network using mutual information and conditional independence
نویسندگان
چکیده
منابع مشابه
Gene Regulatory Network Reconstruction Using Conditional Mutual Information
The inference of gene regulatory network from expression data is an important area of research that provides insight to the inner workings of a biological system. The relevance-network-based approaches provide a simple and easily-scalable solution to the understanding of interaction between genes. Up until now, most works based on relevance network focus on the discovery of direct regulation us...
متن کاملA Scoring Function for Learning Bayesian Networks based on Mutual Information and Conditional Independence Tests
We propose a new scoring function for learning Bayesian networks from data using score+search algorithms. This is based on the concept of mutual information and exploits some well-known properties of this measure in a novel way. Essentially, a statistical independence test based on the chi-square distribution, associated with the mutual information measure, together with a property of additive ...
متن کاملExact Test of Independence Using Mutual Information
Using a recently discovered method for producing random symbol sequences with prescribed transition counts, we present an exact null hypothesis significance test (NHST) for mutual information between two random variables, the null hypothesis being that the mutual information is zero (i.e., independence). The exact tests reported in the literature assume that data samples for each variable are s...
متن کاملConditional independence testing based on a nearest-neighbor estimator of conditional mutual information
Conditional independence testing is a fundamental problem underlying causal discovery and a particularly challenging task in the presence of nonlinear and high-dimensional dependencies. Here a fully non-parametric test for continuous data based on conditional mutual information combined with a local permutation scheme is presented. Through a nearest neighbor approach, the test efficiently adapt...
متن کاملDirected Information and Conditional Mutual Information
We study directed information in Bayesian networks and related structures. Mutual information is split into directed information and residual information. Some basic equations for directed information and residual information are determined.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMC Bioinformatics
سال: 2010
ISSN: 1471-2105
DOI: 10.1186/1471-2105-11-s3-s9